Study of Genes that Affect the Severity of CF Disease
The University of North Carolina
at Chapel Hill and Case Western Reserve University are the coordinating
centers for a multi-center trial interested in studying DNA from
volunteers with Cystic Fibrosis (CF) to determine if modifier genes may
affect the clinical course of CF lung
disease. In addition, researchers at the University of
North Carolina are studying modifier genes that may play a role in the
development of CF liver disease.
Modifier genes are genes, other than the CF gene (CFTR), which may
directly or indirectly have an affect on how the body responds to the
conditions that develop as the result of defective CFTR.
Scientists have long wondered why some patients with CF are sicker than
others. They have learned that different mutations (changes) in
the CF gene may affect the severity of CF lung disease. However,
there is still a wide range in the severity of the disease even among
people who had the same CF genotype (form of the CF gene).