Lung Study
Volunteers, age 8 or older, with a CF genotype of  DF508/DF508 or two known CFTR genotype alleles (see list below) may be eligible. If you decide to participate, you will be one of approximately 1500 subjects from around the country participating in this study. We will collect a blood sample from you, for DNA testing, and review some clinical information about your disease course. We are particularly interested in those volunteers greater then 32 years old.  Privacy will be protected.

CFTR Genotype Alleles

DF508              G542X          G551D           R553X
W1282X           N1303K        3905insT        1078delT
621+1G>T        DI507           R560T            S549N
3659delC          G480C         1717-1G>A
Any stop mutation (CFTR Genotype ending in “X”)

Liver Study
Volunteers with CF, regardless of genotype and age, who have “severe” liver disease with portal hypertension (big spleen, i.e. “splenomegaly” and/or esophageal varices) may be eligible to participate.  This would include any person who has been evaluated for a liver transplant, or has already received a liver transplant. If you participate, you will be one of approximately 500 individuals worldwide contributing to this study.  We will collect a blood sample from you, for DNA testing, and review some clinical information about your disease course.  Privacy will be protected.

 



 

 

This site was developed at UNC Chapel Hill in conjunction with the UNC-CH School of Medicine and the Cystic Fibrosis Foundation.
Copyright © 2006 UNC Chapel Hill Pulmonary Research and Treatment Center, All Rights Reserved.
Updated Feb 6, 2006